Effect of Tyrosine Kinase Inhibitors on Renal Functions by Özgür Can in Journal of Urology &
Nephrology Studies in Lupine publishers
Background:
We aim to document if any difference exists for renal functions between metastatic and nonmetastatic patients.
Methods:
The study population included 12 metastatic and 15 non-metastatic patients. Metastatic renal cancer patients using the TKIs were compared to non- metastatic patients.
Results:Preoperative estimated glomerular filtration rate (e-GFR) was significantly low in metastatic patients than non-metastatic patients (p: 0.048). A trend toward increased acute kidney injury during hospital stay in the non-metastatic group was observed, but this fell just short of statistical significance (p:0.109). Two groups did not differ significantly in terms of postoperative e-GFR (p: 0.256). No statistically significant differences were observed in actual e- GFR between two groups (p: 0.638). No statistically significant differences were found in pre-TKIs and post-TKIs e-GFR values (p: 0.735). Proteinuria was statistically more common in metastatic patients than non-metastatic patients (p<0.001). No statistically significant difference in age, sex, follow-up period, NSAIDs use, antihypertensive and ARBs/ACEIs use were documented between the two groups.
Conclusion: Increased risk for proteinuria was documented in metastatic patients with TKIs use. However, use of the TKIs had no effect on e- GFR. No statistically significant differences were observed in actual e- GFR between two groups.
https://www.lupinepublishers.com/urology-nephrology-journal/pdf/JUNS.MS.ID.000106.pdf
https://www.lupinepublishers.com/urology-nephrology-journal/abstracts/effect-of-tyrosine-kinase-inhibitors-on-renal-functions.ID.000106.php
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