Wednesday, November 28, 2018

Prevalence and Risk Factors of Post-Transplantation Diabetes Mellitus in Patients after Kidney Allotransplantation in Moscow: (JUNS)-Lupine publishers



Purpose:To find out the prevalence, and the risk factors conducive to the development of post-transplantation diabetes mellitus (PTDM) after kidney allotransplantation (KAT).
Methods: The medical histories of 146 recipients of kidney allotransplants received between 1989 and 2014 were reviewed in retrospect. Diabetes mellitus diagnosed before KAT was a criterion for exclusion from the study. Analysed as risk factors were: sex, age, KAT time, and the use of glycocorticoids (GCs), tacrolimus (Tc), and/or cyclosporine A (CcA). The veritability of their influence was assessed using the step-wise linear regression analysis method.
Results: The recipients’ average age was 42.9 +/- 20.2 (х±σ) years at the time of the study. PTDM prevalence in the general group was 21.9% (n=32). Age and the use of calcineurin inhibitors (CNIs) and GCs had the greatest impact on PTDM development  (р=0,01).


https://www.lupinepublishers.com/urology-nephrology-journal/pdf/JUNS.MS.ID.000108.pdf

https://www.lupinepublishers.com/urology-nephrology-journal/abstracts/prevalence-and-risk-factors-of-post-transplantation-diabetes-mellitus-in-patients-after-kidney-allotransplantation-in-moscow.ID.000108.php

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Thursday, November 22, 2018

Presentation and Outcomes of First-Degree Relatives Treated with Brachytherapy for Clinically Localized Prostate Cancer: (JUNS)- Lupine publishers



Presentation and Outcomes of First-DegreeRelatives Treated with Brachytherapy forClinically Localized Prostate Cancer by Oren Factor in Journal of Urology &Nephrology Studies in Lupine publishers

Purpose: To determine if first-degree relatives treated with definitive radiation for clinically localized prostate cancers have similar baseline characteristics and clinical outcomes. Methods: From a prospectively assembled database, we identified a set of first-degree relatives with clinically localized prostate adenocarcinoma. Patients were treated with brachytherapy with or without external beam radiation therapy. Biochemical failure was the primary outcome. Toxicities were measured with the International Prostate Symptom Score (IPSS) and Mount Sinai Erectile Function Score (MSEF). Results: We identified 41 patients including 22 pairs of first-degree relatives. One family included 3 separately treated brothers. The median follow up was 72 months. Eight pairs of first-degree relatives presented with the same Gleason score, representing 36% of pairs. Eleven pairs of relatives (50%) fell in the same NCCN risk category. There were 4 total biochemical failures, representing 9.8% of the cohort. In a single pair of brothers both patients experienced a biochemical failure. Therefore, in two pairs of relatives (9.1%) a different biochemical outcome was experienced. In the pair of brothers who both experienced biochemical failure, both brothers developed metastatic disease. One of the brothers died due to prostate cancer. Amongst pairs of first-degree relatives, 10 pairs (52%) experienced a concordant change in IPSS relative to the average. Fifty percent of pairs experienced concordant changes in MSEF score. Conclusion: First-degree relatives treated with radiation therapy did not present similarly. Outcomes appeared to be concordant amongst relatives. There was no suggestion of worse outcomes in patients with a brother or father having prostate cancer.

https://www.lupinepublishers.com/urology-nephrology-journal/fulltext/presentation-and-outcomes-of-first-degree-relatives-treated-with-brachytherapy-for-clinically-localized-prostate-cancer.ID.000107.php 

https://www.lupinepublishers.com/urology-nephrology-journal/pdf/JUNS.MS.ID.000107.pdf

https://www.lupinepublishers.com/urology-nephrology-journal/abstracts/presentation-and-outcomes-of-first-degree-relatives-treated-with-brachytherapy-for-clinically-localized-prostate-cancer.ID.000107.php

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Tuesday, November 20, 2018

Effect of Tyrosine Kinase Inhibitors on Renal Functions: (JUNS)-Lupine publishers



Effect of Tyrosine Kinase Inhibitors on Renal Functions by Özgür Can in Journal of Urology &
Nephrology Studies in Lupine publishers

Background:
We aim to document if any difference exists for renal functions between metastatic and nonmetastatic patients. 
Methods: 
The study population included 12 metastatic and 15 non-metastatic patients. Metastatic renal cancer patients using the TKIs were compared to non- metastatic patients. 
Results:Preoperative estimated glomerular filtration rate (e-GFR) was significantly low in metastatic patients than non-metastatic patients (p: 0.048). A trend toward increased acute kidney injury during hospital stay in the non-metastatic group was observed, but this fell just short of statistical significance (p:0.109). Two groups did not differ significantly in terms of postoperative e-GFR (p: 0.256). No statistically significant differences were observed in actual e- GFR between two groups (p: 0.638). No statistically significant differences were found in pre-TKIs and post-TKIs e-GFR values (p: 0.735). Proteinuria was statistically more common in metastatic patients than non-metastatic patients (p<0.001). No statistically significant difference in age, sex, follow-up period, NSAIDs use, antihypertensive and ARBs/ACEIs use were documented between the two groups.

Conclusion: Increased risk for proteinuria was documented in metastatic patients with TKIs use. However, use of the TKIs had no effect on e- GFR. No statistically significant differences were observed in actual e- GFR between two groups.

https://www.lupinepublishers.com/urology-nephrology-journal/fulltext/effect-of-tyrosine-kinase-inhibitors-on-renal-functions.ID.000106.php

https://www.lupinepublishers.com/urology-nephrology-journal/pdf/JUNS.MS.ID.000106.pdf

https://www.lupinepublishers.com/urology-nephrology-journal/abstracts/effect-of-tyrosine-kinase-inhibitors-on-renal-functions.ID.000106.php

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Thursday, November 15, 2018

Clinico-Functional Characteristics of Left Ventricular Dysfunction in Patients with Glomerulopathies and Their Relationship to Morphological Changes in The Kidneys: (JUNS)-Lupine publishers



Clinico-Functional Characteristics of Left Ventricular Dysfunction in Patients with Glomerulopathies and Their Relationship to Morphological Changes in The Kidneys by Aiypova Dinara in Journal of Urology & Nephrology Studies in Lupine publishers

Purpose:To study the possible association of cardiac function with morphological changes of the kidneys in glomerulopathies.
Materials and Methods: 55 patients with GP were examined (32 men, 23 women) aged from 17 to 58 (on the average 32.76 ±10.3) years. Given the high prevalence left ventricular systolic diastolic dysfunction in patients with GP with impaired renal function,analyzed the data of patients with CKD stages 1-3. The mean GFR was 87.92 ± 28.2 ml / min / 1.73 m2. Histology, immunofluorescence and electron microscopic method of investigation were used in the study of nephrobiopsy data.

https://www.lupinepublishers.com/urology-nephrology-journal/fulltext/clinico-functional-characteristics-of-left-ventricular-dysfunction-in-patients-with-glomerulopathies-and-their-relationship-to-morphological-changes-in-the-kidneys.ID.000105.php

https://www.lupinepublishers.com/urology-nephrology-journal/pdf/JUNS.MS.ID.000105.pdf

https://www.lupinepublishers.com/urology-nephrology-journal/abstracts/clinico-functional-characteristics-of-left-ventricular-dysfunction-in-patients-with-glomerulopathies-and-their-relationship-to-morphological-changes-in-the-kidneys.ID.000105.php

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Tuesday, November 13, 2018

Contrast-Induced Nephropathy: Current practice: (JUNS)-Lupine publishers


Contrast-Induced Nephropathy: Current practice by Sonali Gupta in Journal of Urology &Nephrology Studies in Lupine publishers

Contrast induced nephropathy (CIN) is a common cause of hospital acquired acute kidney injury (AKI) and associated with adverse clinical outcomes. There is still debate regarding the exact definition, which has greatly influenced the reported incidence of CIN in literature. Recent studies have challenged the universal concern regarding risk of CIN in general population. It is found to occur more commonly after intra-arterial (IA) administration of contrast as in interventional cardiology and vascular procedures especially in patients with multiple comorbidities and underlying renal impairment. Recent studies report negligible risk after intravenous (IV) contrast administration for modern diagnostic radiological examinations. Since it is a potentially preventable clinical condition, it is imperative for health care professional to be well aware of this entity. All patients undergoing iodinated contrast exposure should be risk stratified and preventive measures should be employed in high risk population. This paper will review the epidemiology, controversies regarding definition, pathophysiology, risk stratification, iodinated contrast commonly used in practice and preventive strategies.


Friday, November 9, 2018

The Role of Chemotherapy in Triple Negative Breast Cancer: (JUNS)- Lupine publishers



Breast cancer (BC) is the most frequent tumor worldwide. Triple-negative BCs are characterized by the negative estrogen and progesterone receptors and negative HER2, and represent 12-18% of all BCs. Breast cancer (breast cancer) is the most common oncological disease in women in the Uzbekistan. Data from epidemiological studies show that TNBC is more common in young women (up to 50 years) before menopause. In addition, the likelihood of TNBC is higher in women with early menarche, the first pregnancy at an earlier age, a short period of breastfeeding, and an increased body mass index. It should be not that the prognosis for TNBC does not depend on the degree of differentiation of the tumor, the presence of lymph node metastases, the size of the tumor or the treatment performed. The aggressiveness of TNBC was also confirm by the maximum risk of recurrence during the first three years after surgical treatment with a maximum mortality within the first 5 years. TNBC is a subtype of tumors with a special character of metastasis. Based on the above, we have undertaken the present work, having set ourselves the following goal: to improve immediate and long-term results of treatment of patients with locally advanced thyroid cancer by using the most effective diagnostic methods and comprehensive treatment.  

Radiology; USG and Colour Doppler of Post Renal Transplant Complications

  Abstract Kidney transplant is the treatment of choice for patients with end-stage renal disease. Kidney transplant offers better...